Regulation of protection and immunopathology during infectious diseases by the type 2 cytokines

Dr. Christoph Hölscher (Forschungszentrum Borstel, AG Infektionsimmunologie)

We found that IL-4 receptor-alpha (Ra)-dependent mechanisms - most likely in alternatively activated macrophages - are involved in reactivation and granuloma necrosis during experimental tuberculosis and facilitate persistence during chronic T. cruzi infection. Currently, we are trying to disclose IL-4Ra downstream mechanisms that mediate persistence, reactivation and pathology during chronic infectious diseases.

Laufzeit: 2008-2010
Förderung: BMBF Förderschwerpunkt "Resistenz und Empfänglichkeit gegenüber Infektionen" (BMBF)

Kooperationspartner:

  • St. Jude Children's Research Hospital, Memphis, TN, USA
    Departments Infectious Diseases - Immunology
    Peter Murray, PhD
    Webiste
  • University of Cape Town, Southafrica
    Immunology of Infectious Disease Research Unit
    Prof. Dr. Frank Brombacher
    Wesite
  • Universität zu Lübeck
    Institut für Anatomie
    Dr. rer. nat. Katrin Kalies
    Website