Immunosuppressive agents differently suppress T cell subpopulations

Prof. Dr. med. Sonja Schrepfer
(AG Transplant and Stem Cell Immunobiology (TSI)
PD Dr. Tobias Deuse
(AG Herz- und Lungentransplantation)

The recent discovery of a CD4+ T cell subtype characterized by the secretion of interleukin IL-17 (Th-17 cells) had a major impact on our understanding of immune processes not readily explained by the Th-1/Th-2 paradigm. We are investigating the efficacy of each member of the main immunosuppressive substance classes to specifically suppress activated lymphocyte subpopulations.

Laufzeit seit 2008

Kooperationspartner:

  • Stanford Universität, Kalifornien, USA
    Cardiothoracic Surgery (CT)
    Prof. Dr. R.C. Robbins
    CT Surgery
  • Stanford Universität, Kalifornien, USA
    Pathology
    Prof. Dr. A. Connolly
    Pathology