Regulation of the macrophage cytoskeleton during infectious processes

Prof. Dr. Martin Aepfelbacher / PD Dr. Ruckdeschel (Institut für Medizinische Mikrobiologie, Virologie und Hygiene)

Migration of macrophages to sites of infection, subsequent uptake and intracellular processing of pathogens all depend on the dynamic reorganization of the macrophage cytoskeleton. In this context, we investigate the fine-tuned regulation of the actin and tubulin cytoskeletons as well as the intracellular transport processes that are critical for successful elimination of pathogens by the innate immune system.

Group leader: Prof. Dr. rer. nat. S. Linder
Website

Aktin- und Tubulin-Zytoskelett eines primären humanen Makrophagen. Aktin-reiche Podosomen sind in Rot erkennbar, das Tubulin-Zytoskelett ist in Grün dargestellt.

Kontakt von Borrelia burgdorferi (rot) mit einem primären humanen Makrophagen (grün)