Molecular and functional analyses of CD25 as a target for ADP-ribosylation on CD4+/CD25+ regulatory T cells

Prof. Dr. Friedrich Nolte (AG Molekulare Immunologie)

The goal of the proposed project is to identify the arginine residue in CD25 that serves as the acceptor for ADP-ribosylation and to determine the consequences of this modification for the function of CD25. Moreover we will evaluate the effects of CD25-ADP-ribosylation on the function of regulatory T cells.

Laufzeit: 2006-2009
Förderung: DFG: Einzelförderung