Mouse models to assess the role of RUNX1 mutations and FLT3-signalling events in the establishment and maintenance of acute leukaemia

Dr. Carol Stocking (Heinrich-Pette-Institut)

FLT3 receptor tyrosine kinase is an important regulator of early lymphoid and myeloid progenitors - and is mutated at a relatively high incidence of acute leukemias. In AML patient samples with an undifferentiated phenotype, FLT3 mutations are often accompanied with mutations in the RUNX1 transcription factor. Our goal is to determine the role of these mutations in normal differentiation and leukemia induction.

Laufzeit: 01.07.2008-30.06.2011
Förderung: Deutsche Krebshilfe

Kooperationspartner

  • Johann Wolfgang Goethe-Universität Frankfurt am Main - Medizinische Klinik II
    Klinikum und Fachbereich Medizin
    Prof. Dr. Hubert Serve
    Website
  • Forschungsinstitut Kinderkrebs-Zentrum Hamburg
    Prof. Dr. Martin Horstmann
    Website