The Karyopherin CRM1 is Required for CD83 Expression

Prof. Dr. Joachim Hauber (Heinrich-Pette-Institut)

Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system and are specialized to activate T cell-dependent immune responses. Mature DC are characterized by expression of CD83, a surface molecule that has been postulated to be required for efficient DC activity. Here we show, that the nuclear export receptor CRM1 is nessecary for CD83 mRNA export and subsequently for CD83 expression in human DC.

Laufzeit: bis Sommer 2010
Förderung: DFG/CH 668/1-1

Kooperationspartner

  • Georg-August-Universität Göttingen
    Zentrum für Biochemie und Molekulare Zellbiologie - Abteilung Biochemie I
    PD Dr. Ralph H. Kehlenbach
    Website
  • Universitätsklinikum Erlangen
    Hautklinik / Experimentelle Dermatologie
    Prof. Dr. Alexander Steinkasserer
    Website