Rolle der natürlichen Killer (NK)-Zellen, NK-ähnlichen und NK-T-Zellen bei der Primär-TB in Kindern

Dr. Marc Jacobsen (Bernhard-Nocht-Institut, AG Dr. Jacobsen)

The impact of NK, NK-like, and NKT cells remains elusive. These immune the cells exert an important function at the boarder between innate and adaptive immunity. This includes crucial immune modulatory and immune polarizing functions. Although NKT cells have been shown to protect mice from TB, their role in human TB is unknown. In this context we investigate the frequency, phenotype and cytokine expression pattern of NK, NK-like, and NKT cells in children with TB and LTBI fluorescence activated.

Laufzeit: vorerst bis 2009

Kooperationspartner:

  • Universitätsklinikum Hamburg-Eppendorf
    I. Medizinische Klinik und Poliklinik
    Dr. Stefan Schmiedel
    UKE, I. Medizinische Klinik und Poliklinik
  • Universitätsmedizin Berlin-Charité
    Klinik für Pädiatrie M.S. Pneumologie und Immunologie
    Dr. Klaus Magdorf
    Website