T-Zellzytokin-Muster Expression und Phänotyp in Kindern mit latenter M. tuberculosis Infektion und Kindern mit TB

Dr. Marc Jacobsen (Bernhard-Nocht-Institut, AG Dr. Jacobsen)

The phenotype, antigen specificity and function of TB-specific T cells are investigated. Especially the cytokine expression pattern and memory status are analyze fort their discriminative efficacy between children with LTBI and TB. Characterization of the T cell response essential for protective immunity against M. tuberculosis and long-lasting memory has major implications for vaccine development and immune intervention based strategies.

Laufzeit: vorerst bis 2012
Förderung: DFG

Kooperationspartner:

  • Universitätsmedizin Berlin-Charité
    Klinik für Pädiatrie, M.S., Pneumonologie und Immunologie
    Tuberkulose-Forschung
    Dr. Klaus Magdorf
    Website
  • Stellenbosch University, Südafrika
    Faculty of Health Sciences- Molecular Biology and Human Genetics
    Prof. Gerhard Walzl
    Website
  • Stellenbosch University, Südafrika
    Tygerberg Hospital, Cape Town
    Prof. Dr. Anneke Hesseling
    Desmond Tutu tb center
    Director Paediatric TB Research Program
    Website