Immunpolarisierung: Ko-Infektionen durch Darm-Helminthen und wie diese die T-Zellantwort gegen M. tuberculosis beeinflussen

Dr. Marc Jacobsen (Bernhard-Nocht-Institut, AG Dr. Jacobsen)

The aim of this project is to define the epidemiologic and immunologic characteristics of childhood TB, assuming that a phenomenon called immune polarization is a crucial factor in the development of immunity against TB. An influence of infections with parasitic helminths – which has been shown.
Consequently we will determine the influence of worm infection as well as deworming on the clinical presentation and severity of TB disease.

Laufzeit: vorerst bis 2012
Gefördert durch: DFG

Kooperationspartner:

  • Universitätsmedizin Berlin-Charité
    Klinik für Pädiatrie, M.S., Pneumonologie und Immunologie
    Tuberkulose-Forschung
    Dr. Klaus Magdorf
    Website
  • Stellenbosch University, Südafrika
    Faculty of Health Sciences- Molecular Biology and Human Genetics
    Prof. G. Walzl
    Website
  • Stellenbosch University, Südafrika
    Tygerberg Hospital, Cape Town
    Prof. Dr. Anneke Hesseling
    Desmond Tutu tb center
    Director Paediatric TB Research Program
    Website
  • Max-Planck-Institut für Infektionsbiologie
    Prof. S.H.E. Kaufmann
    MPII
  • Ovamed GmbH, Hamburg
    N. Abromeit
    Website