Characterization of inflammatory cells and mediators in human rapidly progressive glomerulonephritis

Prof. Dr. R.A.K. Stahl (AG Leukocytes and Renal Inflammation)

We will study the composition and distribution of active disease-related inflammatory infiltrates in kidney biopsy specimens from patients with RPGN. Particularly subsets of T cells, B cells, macrophages, dendritic cells and granulocytes as well as expression of genes involved in their recruitment, activation and effector mechanisms will be characterized. In a prospective study, we will study their impact on clinical disease activity, course and outcomes.

Laufzeit: bis 09. 2012
Förderung: DFG
Klinische Forschergruppe "Immunopathogenesis and Therapy of Glomerulonephritis" KFO 228

Kooperationspartner

  • Universitätsklinikum Bonn, Immunologie
    Prof. C. Kurts
    Website
  • Universitätskrankenhaus Hamburg-Eppendorf, Institut für Immunologie
    Prof. Hans-Willi Mittrücker
    AG Infektionsimmunologie
  • Universitätskrankenhaus Hamburg-Eppendorf, Experimentelle Hepatologie + Immunologie
    Prof. Dr. Gisa Tiegs
    AG Experimentelle Immunologie und Hepatologie
  • Zentrum für Molekulare Neurobiologie Hamburg (ZMNH)
    Prof. Rolf Martin / Frau Dr. Mireia Sospedra
    ZMNH
  • Universitätskrankenhaus Hamburg-Eppendorf, III. Medizinische Klinik
    Prof. Dr. Ulf Panzer; Prof. Friedrich Thaiss
    UKE, III. Medizinische Klinik