Function of chemokine receptors in T cell mediated glomerulonephritis

Prof. Dr. Ulf Panzer (AG Chemokines and Renal Inflammation)

Recruitment of T cells into the kidney is a hallmark of glomerulonephritis and is correlated to renal function. It has been assumed that the cell-mediated immune reaction in rapidly progressive glomerulonephritis is predominantly of the Th1 type. Recently, however, this concept has been challenged by the identification of a new IL-17-producing CD4+ effector T cell subset (Th17 cells) that might be responsible for immune-mediated effects previously attributed to the Th1 pathway.

Chemokines play a crucial role in the regulation of T cell trafficking and activation. Their effects are mediated by chemokine receptors that are predominantly expressed by leukocytes. Th1-polarized cells preferentially express CXCR3, CCR5, and CXCR6, whereas CCR6 and CXCR3 have been detected on Th17 cells. However, the chemokine receptor expression profile of T cell subsets has yet to be fully elucidated, particularly with respect to functional importance.

An improved understanding of chemokine regulated renal T cell trafficking and consecutive tissue injury will facilitate the targeting of specific chemokine receptors for the treatment of T cell-mediated glomerulonephritis.

Laufzeit: bis 09. 2012
Förderung: DFG
Klinische Forschergruppe "Immunopathogenesis and Therapy of Glomerulonephritis" KFO 228

Kooperationspartner

  • Universitätsklinikum Bonn, Immunologie
    Prof. C. Kurts
    Website
  • Universitätskrankenhaus Hamburg-Eppendorf, Institut für Immunologie
    Prof. H.-W. Mittrücker
    AG Infektionsimmunologie
  • Universitätskrankenhaus Hamburg-Eppendorf, Experimentelle Hepatologie + Immunologie
    Prof. Dr. Gisa Tiegs
    AG Experimentelle Immunologie und Hepatologie
  • Zentrum für Molekulare Neurobiologie Hamburg (ZMNH)
    Prof. R. Martin / Frau Dr. Sospedra
    ZMNH
  • Universitätskrankenhaus Hamburg-Eppendorf, III. Medizinische Klinik
    Prof. RAK Stahl + Prof. F. Thaiss
    UKE, III. Medizinische Klinik

siehe auch KFO 228