Mechanisms of neurodegeneration in chronic central nervous system inflammation

Dr. Manuel Friese (AG Neuroimmunologie)

We will characterise molecules, which might be involved in neurodegeneration during chronic CNS inflammation. We will investigate the pathophysiological role of different ion channels for neuronal degeneration and inflammation in an animal model of MS.
This analysis will be done by utilizing pharmacological blockade and by using respective knockout mice followed by an investigation into the mechanisms of action. An understanding of the contribution of ion channels could lead to novel treatments.


  • Universitätsklinikum Hamburg-Eppendorf
    Institut für Biochemie und Molekularbiologie I
    Zelluläre Signaltransduktion
    Prof. Dr. Andreas Guse
    UKE, Institut für Biochemie und Molekularbiologie I
  • University of Oxford
    Weatherall Institute of Molecular Medicine
    Prof. Dr. Lars Fugger
  • Universität Homburg - Universitätsklinikum des Saarlandes
    Institut für experimentelle und klinische
    Pharmakologie und Toxikologie
    Allgemeine Pharmakologie
    Prof. Dr. Veit Flockerzi und Prof. Dr. Marc Freichel
  • Evotec AG Hamburg
    Dr. Rita Reifegerste