Fine-tuning of infection-induced inflammatory immune responses by gp130 family cytokines

Dr. Christoph Hölscher (Forschungszentrum Borstel, AG Infektionsimmunologie)

We found that IL-6/IL-23-driven T helper (TH)17 cells are critical for maintaining protective TH1 immune responses during chronic infection. On the other hand, we could shown that IL-27 and IL-35 can modulate excessive TH17 inflammation and both prevents optimal anti-microbial protection and limits the pathological sequelae of chronic inflammation. Further analysis will unravel the TH17-dependent mechanisms mediated e.g. by IL-17, IL-21 or IL-22.

Laufzeit: 2008-2010
Förderung: EXC 306 IRN F "Cytokine signalling via gp 130",
project 4 "Infection driven inflammation"

Kooperationspartner:

  • Institut für Biochemie, Christian-Albrechts-Universität zu Kiel
    Prof. Dr. Jürgen Scheller
    Website
  • Conaris - Research Institute AG
    Dr. Dirk Seegert
    Website
  • Bernhard-Nocht-Institut für Tropenmedizin Hamburg
    PD Dr. Thomas Jacobs
    BNI/AG PD Dr. Jacobs
  • Bernhard-Nocht-Institut für Tropenmedizin Hamburg
    PD Dr. Hanna Lotter
    BNI/Abteilung für Molekulare Parasitologie
  • Institut für Immunologie, Veterinärmedizinische Fakultät, Universität Leipzig
    Prof. Dr. Gottfried Alber
    Website